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Robaxin is a muscle relaxant. It is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
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Generic form of robaxin (1.4-8.5 mg), a cannabinoid receptor agonist what is the generic for robaxin that induces apoptosis through the inhibition of cell proliferation and survival; (3) cannabidiol (2.2-4 mg), a nonpsychoactive cannabinoid with antitussive properties; (4) delta-9-tetrahydrocannabinol (9.6-18.7 mg), which acts as a CB 1 and 2 cannabinoid receptor agonist; (5) anandamide (1.4-10 mg), a cannabinoid receptor antagonist.
Drug efficacy and adverse effects
Although the study had a randomized design, it is not clear in particular which group received the highest dose and which group received the lowest dose of cannabinoids tested (Supplementary Table 1). In one study, no significant difference was found in mean change total scores between the cannabinoid and placebo groups (mean difference, 4.2 points out of a possible 6 points; P = 0.18). However, the mean difference in change scores the CB 1 -treated group was greater than that found in the placebo group (mean difference, 23.4 points; P = 0.005), whereas mean change scores in the CB 2 -treated group were not significantly different from those in the placebo group (mean difference, 7.1 points; P = 0.13). In another study, patients who received oral Dronabinol 4 mg daily over weeks demonstrated better clinical outcomes than patients who received robaxin 750 vs soma
placebo or with lower doses of Dronabinol. The mean change score in Dronabinol-treated group was 6.4 (95% confidence interval 4.7 to 6.9) points greater than the mean change score in placebo-treated group (P < 0.001). There were no clinically significant differences between the patients who received treatment, and the patients who did not receive treatment, on clinical variables of global improvement, pain, or quality of life. In addition to these clinical improvements, patients who received oral Dronabinol 4 mg daily during weeks experienced a decrease in urinary excretion of plasma cannabinoids (approximately 50% decrease) and a significant decrease in plasma concentrations of nabilone (approximately 40% decrease.) The mean percentage change scores for these variables in the Dronabinol 4 mg and placebo-treated groups were 7.0 (95% confidence interval 5.4 to 7.7) and 6.3 (95% confidence interval 6.6 to 6.8), respectively (P = 0.06.)
In summary, patients with advanced chronic neuropathic pain who are resistant to or unwilling undergo alternative therapeutic modalities, oral dronabinol may be an efficacious and safe treatment option.
Adverse events relate